Every batch is adjusted to the same bioactive profile and released against a reference specification. The number on the certificate is the number in the drum.
Evidence-backed plant bioactives
The operating system for botanical biotechnology
We turn plant bioactives into standardized, evidence-backed ingredients for clinical nutrition, functional foods, nutraceuticals, pharmaceuticals and animal health.
Absorbance / mAU Compound profile · illustrative
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Built for
Clinical Nutrition Functional Foods Nutraceuticals Pharmaceutical Animal Health & Aquaculture
We generate global solutions with science.
Platform
We don’t ship a plant. We ship a specification.
A botanical extract only becomes useful to a formulator when its bioactive profile is defined, reproducible and transferable to industrial volume. That is the entire job — and it is where most plant-derived ingredients fail.
Activity is confirmed in experimental models before an ingredient leaves research. Nothing moves forward on a literature claim alone.
Processes are designed in the lab to survive the transfer to industrial volume, because a result that only works at bench scale is not a product.
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PaloNegro laboratory: analytical instrumentation and scientists at work
Wide shot · 2400×1000 px minimum · own photography
Applications
One platform, five industries.
The same standardized bioactive reaches a clinical formula, a cereal bar, a capsule, a preclinical study and a salmon pellet. What changes is the matrix it has to survive.
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Medical nutrition drink and patient care setting
Clinical Nutrition
Medical nutrition where the formulation has to hold up under scrutiny.
Bioactives designed for oral nutritional supplements and medical drinks, where stability, dosing accuracy and tolerability decide whether a formula reaches the patient.
- Ready-to-drink
- Oral supplements
- Enteral formulas
- Powdered blends
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Functional food and beverage formats
Functional Foods
Turn a processed food into a functional one without rebuilding it.
Ingredients that carry a measurable bioactive load into everyday formats, so a manufacturer can add function to an existing product line instead of launching a new category.
- Cereal bars
- Yogurts
- Functional beverages
- Juices
- Snacks
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Nutraceutical capsules, gummies and powders
Nutraceuticals
Premium supplements built on a standardized active, not a plant powder.
Standardized extracts with a defined bioactive profile, so the label claim on a capsule matches what is actually in it — batch after batch.
- Capsules
- Tablets
- Gummies
- Powders
- Sachets
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Analytical laboratory instrumentation and cell culture research
Pharmaceutical
Plant bioactives as candidates for translational research.
We characterize compounds against relevant biological models — including cell culture and tumor organoid work — to identify actives with therapeutic potential.
- Active candidates
- Translational research
- Preclinical models
- Analytical dossiers
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Aquaculture, salmon feed pellets and livestock nutrition
Animal Health & Aquaculture
Performance and health inputs for feed at industrial scale.
Bioactives formulated for feed matrices, where the ingredient has to survive processing, stay stable in the pellet and remain viable at production cost.
- Salmon feed
- Pellets
- Livestock
- Pet nutrition
Research
Where plant compounds have something real to offer.
We run research programmes on the conditions where dietary bioactives have a plausible, measurable effect — and we advance a candidate only when the result reproduces across models.
GLY
Glycemic regulation
Compounds evaluated for their effect on glucose handling and insulin response, aimed at formulations for metabolic risk populations.
- Cell culture
- Enzymatic assays
- In vivo models
INF
Inflammation
Anti-inflammatory activity screened across inflammatory pathways, with candidates advanced only when the effect reproduces across models.
- Cytokine panels
- Cell culture
- Organoids
MET
Metabolic disease
Bioactives studied against the cluster of metabolic conditions where diet-derived compounds have a plausible, measurable role.
- In vivo models
- Metabolomics
- Biomarker panels
GUT
Gut health
Effects on intestinal barrier function and microbial ecology, evaluated with the digestive models the food industry actually accepts.
- Intestinal organoids
- Microbiota assays
- Digestion models
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Tumor organoids and cell culture under advanced microscopy
Microscopy imagery · own or licensed
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Chromatography and analytical equipment in the PaloNegro laboratory
Instrumentation close-up · own photography
Artificial intelligence
AI proposes. The laboratory decides.
We use advanced computational tools to accelerate the discovery of new bioactives — and then we test them. Every result obtained through AI is validated experimentally with current analytical technology before it becomes an ingredient.
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Models
Chemical and biological data feed models that rank which compounds are worth the bench time.
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Candidates
The model narrows thousands of possible bioactives to a shortlist with a testable hypothesis attached.
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Assays
Every shortlisted compound goes to the laboratory. Analytical and biological testing decides, not the prediction.
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Confirmed
Only compounds that hold up experimentally enter development — and the result goes back into the model.
Every assay result feeds back into the model. The loop is the product.
Technology & process
Six steps between a plant and a specification.
Our own biotechnological processes take raw botanical material to a highly standardized, scalable ingredient. Each step depends on the one before it — skip one and the specification stops being reproducible.
- 01Botanical identification
Sourcing
Botanical selection and traceable supply. The starting material is defined before anything is extracted from it.
- 02Green extraction
Extraction
Proprietary extraction processes tuned to the target compound rather than to the plant as a whole.
- 03Preparative chromatography
Purification
Fractionation and purification to isolate the bioactive fraction and remove what carries no function.
- 04HPLC · MS · NMR
Characterization
Chemical identity and concentration confirmed analytically. This is the step that produces the specification.
- 05Batch QC
Standardization
Every batch adjusted to the same bioactive profile, with quality control against the reference specification.
- 06Industrial scale-up
Scale-up
Process transferred to industrial volume without losing the specification that made it work in the lab.
Intellectual property
Protected before it is published.
Our solutions are covered by a deliberate intellectual property strategy. For an industrial partner, that protection is not a legal footnote — it is the reason an exclusive agreement can exist at all.
Patent strategy
Developments are filed before they are disclosed, so publication never costs us the right to commercialize.
Proprietary processes
The extraction and standardization routes are our own. The specification cannot be reproduced by buying the same plant.
Exclusivity
Protection is what makes an exclusive supply or licensing agreement possible for a partner.
Team
Built by scientists, not by a marketing department.
PaloNegro brings together researchers working on natural products chemistry, pharmacology, process engineering and computational discovery — with a shared commitment to solutions that hold up under evidence.
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Chief Scientific Officer
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Natural products chemistry
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Head of Research
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Molecular pharmacology
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Head of Process Development
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Extraction & scale-up
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Analytical Lead
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Chromatography & mass spectrometry
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Head of Computational Discovery
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Machine learning for bioactives
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Quality & Regulatory Lead
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Standardization & compliance
Strategic alliances
Chilean science, international distribution.
Reaching a formulator in another market takes more than a good ingredient. We work with partners who already have the commercial infrastructure to place it there.
Crown Harvest
International distribution Commercial alliance for the international distribution of PaloNegro ingredients.
Partner slot
Reserved for the next distribution or research alliance. Send us the logo and the scope and it goes here.
Contact
Tell us what you need to formulate.
Technical dossier
Specification, analytical profile and stability data for the ingredient you are evaluating.
Sample request
Pilot quantities for formulation trials in your own matrix.
Research partnership
Joint programmes, licensing and exclusive supply agreements.